What’s New in Weight Loss Medication?

Picture of a scale for taking one's weight. Light green background that has a measuring tape laid across it.

Losing weight can be a challenging endeavor; for many individuals, it requires more than just diet and exercise. Weight loss medications can provide an additional tool to help individuals achieve their weight loss goals. In recent years, there have been exciting developments in weight loss medications, with new options that offer promise for those struggling with obesity. Let’s explore some of the latest advancements in weight loss medication.

1. Semaglutide (Ozempic): Semaglutide is an injectable medication originally developed for treating type 2 diabetes. However, recent studies have shown its efficacy in promoting weight loss. Semaglutide has been found to lead to significant weight reduction in individuals with obesity, with some patients achieving weight loss of up to 15% of their initial body weight. Semaglutide works by suppressing appetite, leading to reduced food intake. It has been approved by the U.S. Food and Drug Administration (FDA) for chronic weight management in individuals with obesity.

2. Bupropion/naltrexone (Contrave): Bupropion/naltrexone is a combination medication that regulates two brain areas that regulate appetite and cravings. Bupropion is an antidepressant that also helps reduce food cravings, while naltrexone is used to treat opioid and alcohol addiction and helps suppress appetite. Together, these medications work synergistically to promote weight loss. Contrave has been shown to be effective in helping individuals with obesity lose weight when used alongside a reduced-calorie diet and increased physical activity.

3. Liraglutide (Saxenda): Liraglutide, another medication initially developed for type 2 diabetes treatment, has been repurposed for weight management. It is an injectable medication that acts on the brain to reduce appetite and increase feelings of fullness. Liraglutide has been approved by the FDA for chronic weight management in individuals with obesity or who are overweight with at least one weight-related comorbidity. Studies have shown that liraglutide can lead to significant weight loss when combined with lifestyle modifications.

4. Setmelanotide (Imcivree): Setmelanotide is a breakthrough medication approved by the FDA for treating rare genetic disorders associated with severe obesity. It works by targeting specific pathways in the brain that regulate hunger and satiety. Setmelanotide has shown remarkable efficacy in reducing hunger and promoting weight loss in individuals with specific genetic mutations that cause uncontrolled appetite. While it is currently approved for a limited population, ongoing research explores its potential use in more common forms of obesity.

It is important to note that weight loss medications are typically prescribed to individuals with a body mass index (BMI) of 30 or higher or a BMI of 27 or higher with weight-related comorbidities. These medications should always be used under the guidance of a healthcare professional and in conjunction with a comprehensive weight loss plan that includes dietary changes and increased physical activity.

As with any medication, weight loss medications can have side effects, and their use should be carefully monitored by a physician with training in obesity medicine. Common side effects may include nausea, diarrhea, constipation, or changes in taste. It is essential to discuss potential risks and benefits with your doctor before starting any weight loss medication.

While these advancements in weight loss medication are exciting, it is essential to remember that medication alone is not a magic solution for weight loss. Sustainable weight management involves a healthy lifestyle with a balanced diet, regular physical activity, and behavioral changes. Weight loss medications can be helpful in conjunction with these lifestyle modifications, but they should not be seen as a substitute for healthy habits.

In conclusion, recent years have witnessed significant advancements in weight loss medication. Semaglutide, bupropion/naltrexone, liraglutide, and setmelanotide are among the newer options that offer hope for individuals struggling with obesity. These medications work in various ways to reduce appetite, increase feelings of fullness, and promote weight loss. However, it is important to remember that weight loss medications should always be used under the guidance of a healthcare professional and as part of a comprehensive weight loss plan. By combining medication with healthy lifestyle changes, individuals can enhance their chances of achieving long-term weight loss success.


El Camino Women’s Medical Group offers the latest Minimally Invasive Solutions for gynecologic problems.   Drs. Amy TengErika Balassiano, Pooja Gupta, and Christina Lam, all members of AAGL (American Association of Gynecologic Laparoscopy), are highly trained and experienced in the field of Minimally Invasive Gynecologic Surgery.   Dr. Erika Balassiano has also completed a Minimally Invasive Gynecologic Surgery Fellowship under the supervision of world-renowned Dr. Camran Nezhat.

All of our physicians are El Camino Hospital doctors and operate and deliver at the Mountain View campus.

Serving Mountain View, Los AltosLos Altos HillsAthertonPalo AltoRedwood CityBurlingameSaratogaCupertinoSunnyvale, Los GatosCampbellSan JoseSanta Clara, Silicon Valley, MilpitasFremont, South Bay, East Bay, and North Bay.