COVID-19 mRNA Vaccination During Pregnancy Shows Strong Immune Responses for Mothers and Infants, Study Reveals

Image of a COVID19 viral particle

In recent times, the COVID-19 pandemic has posed significant challenges to public health, with pregnant individuals being particularly vulnerable. However, a groundbreaking cohort study published in JAMA Network Open suggests that COVID-19 mRNA vaccination during pregnancy leads to robust immune responses in both mothers and infants without adverse effects. Furthermore, this article will also touch upon the upcoming COVID-19 booster, set to be released and offered concurrently with the flu vaccine in the fall of 2023. Obstetricians and gynecologists (OBGYNs) endorse taking both vaccines on the same day, even during preconception, pregnancy, and postpartum phases.

COVID-19 mRNA Vaccination during Pregnancy: Key Findings

The cohort study analyzed data from a significant number of pregnant individuals who received mRNA-based COVID-19 vaccines, such as Pfizer-BioNTech and Moderna. Researchers found that these vaccinations triggered a robust immune response in pregnant women, offering them protection against the virus.

A particularly encouraging aspect of the study was that the immune response generated by the COVID-19 mRNA vaccines extended beyond pregnancy, providing mothers with continued protection for nearly six months after giving birth. This is crucial as it helps safeguard both the mothers and their newborns during a critical period when infants are still building their immune systems.

Moreover, the research revealed no concerning adverse outcomes for either the mothers or their infants as a result of receiving the COVID-19 mRNA vaccines during pregnancy. This finding is essential in allaying fears and uncertainties that some pregnant individuals may have had about the safety of vaccination during this crucial time in their lives.

The Importance of Upcoming COVID-19 Booster and Flu Vaccination

As the world continues to grapple with the COVID-19 pandemic, ongoing efforts to combat the virus and its variants are crucial. The development of a COVID-19 booster vaccine, anticipated to be released in the fall of 2023, aims to enhance and prolong the protection provided by the initial vaccine series.

In addition to the COVID-19 booster, healthcare professionals are also advocating for the flu vaccine to be administered simultaneously. Combining the COVID-19 booster and flu vaccination makes it easier for individuals, including pregnant individuals, to stay protected against multiple viral infections during the flu season.

Safety of Concurrent Vaccination during Preconception, Pregnancy, and Postpartum

Obstetricians and gynecologists (OBGYNs) have been closely monitoring the effects of COVID-19 vaccination during pregnancy and have deemed it safe for both the mother and the developing fetus. As a result, they recommend the COVID-19 booster and flu vaccine be administered concurrently, even before conception, during pregnancy, and after childbirth.

Pregnant individuals are at an increased risk of severe illness from COVID-19 due to physiological changes that occur during pregnancy, making vaccination an essential aspect of their protection. By combining the two vaccines, healthcare providers can streamline the vaccination process, ensuring pregnant individuals receive comprehensive protection against both COVID-19 and influenza viruses without compromising their safety.


The cohort study’s findings regarding the COVID-19 mRNA vaccination during pregnancy offer reassuring evidence of its safety and effectiveness. Pregnant individuals can take solace in the fact that they and their infants can benefit from a strong immune response without any adverse outcomes.

As we look forward to the release of the COVID-19 booster and its simultaneous administration with the flu vaccine in the fall of 2023, OBGYNs are confident in recommending both vaccines for pregnant individuals. By getting vaccinated, pregnant individuals can protect not only themselves but also their unborn children from potential complications related to COVID-19 and influenza.

It is essential to consult with healthcare professionals and OBGYNs to understand the most suitable vaccination schedule for each individual’s specific circumstances. Together, we can continue to combat the COVID-19 pandemic and safeguard the health and well-being of mothers and infants alike.



El Camino Women’s Medical Group offers the latest Minimally Invasive Solutions for gynecologic problems.   Drs. Amy TengErika Balassiano, Pooja Gupta, and Christina Lam, all members of AAGL (American Association of Gynecologic Laparoscopy), are highly trained and experienced in the field of Minimally Invasive Gynecologic Surgery.   Dr. Erika Balassiano has also completed a Minimally Invasive Gynecologic Surgery Fellowship under the supervision of world-renowned Dr. Camran Nezhat.

All of our physicians are El Camino Hospital doctors and operate and deliver at the Mountain View campus.

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